|
|
|
|
|
| Garlet,Q.I.; Pires,L.C.; Silva,D.T.; Spall,S.; Gressler,L.T.; Bürger,M.E.; Baldisserotto,B.; Heinzmann,B.M.. |
| (+)-Dehydrofukinone (DHF) is a major component of the essential oil of Nectandra grandiflora (Lauraceae), and exerts a depressant effect on the central nervous system of fish. However, the neuronal mechanism underlying DHF action remains unknown. This study aimed to investigate the action of DHF on GABAA receptors using a silver catfish (Rhamdia quelen) model. Additionally, we investigated the effect of DHF exposure on stress-induced cortisol modulation. Chemical identification was performed using gas chromatography-mass spectrometry and purity was evaluated using gas chromatography with a flame ionization detector. To an aquarium, we applied between 2.5 and 50 mg/L DHF diluted in ethanol, in combination with 42.7 mg/L diazepam. DHF within the range of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sedation; Anesthesia; Rhamdia quelen; Nectandra grandiflora; Cortisol. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100607 |
| |
|
|
| Heldwein,C.G.; Silva,L.L.; Reckziegel,P.; Barros,F.M.C.; Bürger,M.E.; Baldisserotto,B.; Mallmann,C.A.; Schmidt,D.; Caron,B.O.; Heinzmann,B.M.. |
| The objective of this study was to identify the possible involvement of the GABAergic system in the anesthetic effect of Lippia alba essential oil (EO). We propose a new animal model using silver catfish (Rhamdia quelen) exposed to an anesthetic bath to study the mechanism of action of EO. To observe the induction and potentiation of the anesthetic effect of EO, juvenile silver catfish (9.30 ± 1.85 g; 10.15 ± 0.95 cm; N = 6) were exposed to various concentrations of L. alba EO in the presence or absence of diazepam [an agonist of high-affinity binding sites for benzodiazepinic (BDZ) sites coupled to the GABA A receptor complex]. In another experiment, fish (N = 6) were initially anesthetized with the EO and then transferred to an anesthetic-free aquarium... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: False-melissa; Silver catfish; Benzodiazepines; Flumazenil; GABA. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500009 |
| |
|
|
| Silva,L.L.; Garlet,Q.I.; Benovit,S.C.; Dolci,G.; Mallmann,C.A.; Bürger,M.E.; Baldisserotto,B.; Longhi,S.J.; Heinzmann,B.M.. |
| This study evaluated the sedative and anesthetic effects of the essential oils (EO) of Hyptis mutabilis (Rich.) Briq. and their isolated components on silver catfish (Rhamdia quelen). Quantitative chemical differences between the EOs obtained from leaves and inflorescences were verified, and a new chemotype rich in globulol was described. Although there were no significant differences in the time of induction for sedation and anesthesia between the EOs, only the leaf EO at 344 mg/L anesthetized all fish without side effects. Fractionation of the leaf EO was carried out by column chromatography. The isolated compounds [(+)-1-terpinen-4-ol and (-)-globulol] showed different activity from that detected for the leaf EO in proportional concentrations and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silver catfish; (+)-1-Terpinen-4-ol; (-)-Globulol; Sedation; GABA. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000900771 |
| |
|
|
|
